An organisation can select a specific set of GitHub users (typically the org maintainers) to be auto-assigned in GitHub to any Quest Issues and Pull Requests.
This can be done via the Admin dashboard using the Manage Quests menu on the overall listing of an org's Quests:
In the corresponding modal that appears, select default assignees by typing GitHub usernames into the provided interface
Every time a new Quest is started (i.e. a new reward is stashed in a GitHub Issue), the selected user(s) will be auto-assigned on GitHub by @quest-bot.
Every time a new PR is raised against a Quest Issue and loot called against it by a developer seeking to loot the reward, the selected user(s) will be auto-assigned on GitHub by @quest-bot.
Note: As well as managing default Assignees via the Admin dashboard, it is also possible to define custom overrides on a per-Quest basis. Do this using the Manage Quest menu under the respective Quest.